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Thus, this period of endotoxemia represents the first "hit" in a two "hit" model of risk.
We have previously characterized a sheep model of pulmonary fibrosis using a two hit segmental infusion of bleomycin approach [ 13].
If a two hit is found, the algorithm tries to extend the alignment without gaps, resulting in a high-scoring segment pair (HSP).
Through the study of hereditary and sporadic retinoblastomas, Knudson postulated a two hit mechanism which included the process of growth and differentiation in normal tissues (Knudson, 1971).
There appears to be a synergistic interaction between viral infection and allergic sensitization, suggesting a "two hit" model for induction of persistent asthma.
These result strong suggest that oxidative stress, either by itself or as part of a "two hit process", causes neuronal dysfunction, and AD [ 108].
Similar(53)
Trachsel spun a two-hit shutout, striking out seven while walking two, to beat the Pittsburgh Pirates, 3-0.
Mussina had a two-hit shutout through five innings, then got trapped in the worst inning of his career.
In groups 5 8 we created a 'two hit' model of burn followed by sepsis.
A 'two hit' mechanism has been proposed to drive NASH pathogenesis.
To explain the differences in tumour rates between those two forms, Knudson proposed a "two-hit hypothesis".
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