The phrase "a true linkage" is correct and usable in written English.
It can be used when discussing a genuine connection or relationship between two or more elements, such as ideas, concepts, or entities.
Example: "The research findings provide a true linkage between diet and mental health, highlighting the importance of nutrition in overall well-being."
Alternatives: "a genuine connection" or "an authentic relationship."
The upper 95th percentile of the rvalue distribution for unlinked marker pairs (inter-marker distance ≥ 50 cM), widely considered as a threshold useful to separate the true linkage LD from the background LD due to population structure, was equal to 0.096 (close to 0.10).
First, there may be no true linkage for these disorders.
These may be due to chance findings in one analysis, or they may be true linkage that only one method was sufficiently powered to detect.
If disease risk is largely mediated by rare or private causative variants, then individual linkage studies and conservative meta-analytic approaches may fail to produce findings exceeding standard significance thresholds, even in the presence of substantial heritability and true linkage [4].
In this way the detection of true linkage disequilibrium is favored versus just family linkage.
Also note that the independently generated variants do not reflect the true linkage disequilibrium pattern of the human genome.
The international EMS studies did not perform manual matching like in this study so there true linkage rates may have been higher, or lower, depending on the accuracy of the probabilistic matching.
EXPLoRA has a performance at least as good as the state-of-the-art and it is robust even at low signal to noise ratio's i.e. when the true linkage signal is diluted by sampling, screening errors or when few segregants are available.
Assuming the statistical models are replicated and validated by other researchers, EWAS analyses could provide a wealth of target chemicals to clinically investigate for true linkages with disease.
This assumption serves to inflate apparent values of r, increasing the likelihood of detecting true linkage-disequilibrium (at the cost of an increased false positive rate).
