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The score is converted to a true interval score that ranges from 0 (best) to 100 (worst).
Few women knew whether their malignant tumour represented a false-negative mammography scan or a true interval cancer.
Since the difficulty measure in Table 1 now represents a true interval scale, it can be interpreted just like we would use an ordinary ruler.
In particular the summed FPDI scores cannot be interpreted as a true interval scale unless a Rasch analysis is performed [ 36], which was not undertaken for the current study.
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Open image in new window Fig. 10 Sigsbee 2A model and data: True interval velocity model (a) and a CMP gather (b).
The IC rate for the PEDBC is within the expected parameters, with a high proportion of cases of true interval cancers (54.5%) and a low proportion of false negatives (13.6%).
In our study, we found an IC rate at line with the European guidlines recommendation [ 6] and lower than the results reported in other studies [ 15, 19, 20], with a high proportion of cases of true interval cancers (54.5%) and a low proportion of false negatives (13.6%).
But also, since in subsequent rounds the radiologists have access to the prior images taken at preceding rounds, they are in a better position to detect true interval changes.
That way, we obtain the resulting list of (disjoint) significant intervals one for each overlapping cluster— (τ i *, l i * ) for i = 1, 2, …, M. If one of these intervals (τ i *, l i * ) overlaps a true significant interval (dl, l), we say that (dl, l) has been successfully detected.
However, we found that programs with similar proportions of false negative and true interval cancer have a high immediate recall rate too [ 7, 15, 19, 20, 22– 22].
If true interval cancers were a more aggressive subtype of breast cancers, in theory the survival of women with these tumours might be worse than for those whose breast cancer is overlooked, and with increasing screening rounds and more experience the prognosis would be worse.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com