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In essence, the purpose of a true efficacy (or explanatory) trial is to demonstrate that an intervention can work theoretically under optimal conditions ('best-case scenario').
A fully factorial design, although scientifically attractive, was rejected as it was deemed better suited for a true efficacy study given that one of the treatment arms would have been the pill PBO and shame psychosocial treatment.
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This practice, referred to as "publication bias", makes it difficult to evaluate a medication's true efficacy.
However, as the time course of recovery can be lengthy [ 17], and as some patients remain at risk of further exacerbations for several weeks after treatment [ 18, 19], monitoring patients over this prolonged period may provide a more accurate picture of the true efficacy of an antibiotic therapy.
The true efficacy of a programme of agricultural mitigation measures within a catchment to improve water quality can be determined only after a certain hydrologic time lag period (subsequent to implementation) has elapsed.
This suggests that VEI may be an overestimation of the true efficacy against any RVGE over 1 y follow up.
Thus, the ITLS suppression effect we report is an underestimate of the true efficacy of Vmem change to prevent tumor formation (because variability in ectopic channel expression prevented a sizable fraction of the animals from fully recovering a polarized resting potential).
Such models represent an important stage in therapy development, providing a proof of principle of true efficacy as well as safety in vivo.
Machine learning can also help provide a holistic view of the true efficacy of your marketing efforts, and improve results in specific endeavors like predictive lead scoring look at Salesforce's Einstein as an example.
Robins and Tsiatis [ 20] describe the use of AFT models to estimate the true efficacy of a treatment.
These confounding factors make it difficult to interpret the true efficacy of a second-line chemotherapy regimen.
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CEO of Professional Science Editing for Scientists @ prosciediting.com