Minimal differences were observed when comparing the two groups at baseline, 12-month and the 7-year examinations, but the power to detect a true difference at the 7-year examination was small due to the low number of patients finally re-examined.
Null effects are open to a number of interpretations, particularly the possibility of a Type 2 error (i.e., failing to find a true difference due to lack of power or other methodological error).
Furthemore, if confidence intervals overlap or P > 0.05, this does not prove that there is no difference; on the contrary, there is still a possibility that the observation suffers from a type II error (failure to detect a true difference due to inadequate sample size).
Thus, we adopt the criterion that the difference between the two methods should be greater than 1 kb (dashed line Figure 3b) for it to be regarded as a true difference due to the method used.
In addition, in previous exploratory analysis, aneurysm coiling was associated with less angiographic vasospasm and delayed ischemic neurological deficit than surgical clipping; furthermore, Dumont et al. still suggested whether this is attributable to differences in baseline risk factors between clipped and coiled patients or a true difference remained to be proven [ 21].
That is, we may have missed a true difference due to poor statistical power.
This may be a true difference due to the contrast in colony structure between the much smaller A. millepora and the longer branches of Caribbean Acroporas, which may affect the extent to which polyps display functional differences, or it may be a function of technique (high-throughput RNA sequencing vs. microarray containing ~8700 UniGene ids).
Post hoc power calculations were performed, using the effect sizes derived from this study to determine if the study sample had sufficient power to enable a true difference in estimates to be detected if they truly existed [ 23, 24].
Sometimes people think to make a true difference you have to give a lot of money and then giving back gets overwhelming or unachievable for them.
It is difficult to say whether this is a true difference or due to a responder bias, both for adults and for the children's parents/caretakers.
