The AUC represents the probability that a random true associated pathway has a lower score (i.e. P-value or BF) than a random non-associated pathway.
Sensitivity is the true positive rate calculated as the ratio of pathways found to be associated divided by the number of true associated pathways.
This rate was regarded as a true virus associated hospitalization rate for acute respiratory disease in our study population against which currently used models can be validated.
The study suggests that acute removal of hypocretin 1 signalling induces a true hypersomnia associated with generalized decrease of muscle tone that subsequently evolves over time.
A confounder that would mask a true risk associated with vaccination would be of primary concern; it was therefore assumed that those receiving vaccination had a lower prevalence of an unmeasured confounder that was associated with increased risk of fetal death (see supplementary table 4).
However, given our observed main estimate of 0.79, the difference in prevalence between the groups would have to be large and the association with reduced risk of fetal death strong to obscure a true increased risk associated with vaccination.
However, the numerator of cIHR probably underestimated the true numbers of A(H1N1 pdm09 associated hospitalization, as not all the hospitalized cases were tested in a timely manner and some were tested negative due to waning virus titers when admitted into hospital several days after the onset of illness.
Thus if the B cell clones expressing CR6261 and the other cross-reactive mAbs were present in the donor prior to vaccination (as would be expected) then a true recall response associated with differentiation into plasma cells has not likely occurred.
Cutaneous T cell lymphoma is a chronic condition with insidious onset that may be misdiagnosed as AD, complicating assessment of a true lymphoma risk associated with TCIs.
This concordance of results between comparisons of NRs with each of NK and EK suggests that the gain of methylation observed here is a true aberrant event associated with NR formation rather than an epigenetic feature reminiscent of an early developmental stage.
