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In "Eichmann in Jerusalem," Arendt insists that the book is a "trial report".
Instead, we used a variable coding for whether a trial report included a CONSORT-recommended flow diagram as the measure of 'reporting quality' and were therefore able to adjust for this [20].
Thirteen (32%) required or recommended trial registration prior to publication of a trial report.
If a trial report pre-specified a comparison combining treatment arms, these were used.
The median time spent by a scientist on a trial report was 23 minutes (interquartile range 11-38).
We identified 604 instances of discrepancy (appendices 1-3) within a trial report or between reports of that trial.
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16 We are not aware of a trial reporting long term results.
Although CP (750, 75) became widely used in the late 1980s and early 1990s, the justification supporting it comes from a trial reported in 1989 and updated in 1996.
Figure 1 illustrates the association between prior probability and positive predictive value (the chance that a trial reporting a statistically significant result is not reporting a false positive) when subgroup statistical power is varied.
Extra care is required during data extraction; reviewers should identify when a trial reports that an outcome was measured but no results were reported or events observed, and contact with trialists should be encouraged.
Analyses are described in more detail in a full trial report.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com