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In a trial published by Wilkowski et al. this rate was even higher (14/33 patients = 42%)[ 30].
A trial published by Poulsen et al. [ 10] on accelerated radiotherapy could not be included into the meta-analysis, because only disease specific survival, but not overall survival data has been reported.
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A single randomized trial published by Rivers et al. [ 9] showed a mortality benefit when RBC transfusion was administered to patients with severe sepsis in the emergency department as part of a larger goal-directed resuscitation strategy that included fluid and vasopressor support.
The second study, a randomized controlled trial published by Kerlin and colleagues [ 12], evaluated the effect of night-time intensivists on length of stay, mortality, and other outcomes.
A randomized controlled trial published by Borstad et al showed that in case of co-existing complaints (evident SUI) prolapse repair gave a 3 months success rate in curing SUI of 29%.
A prospective randomized trial published by Spinelli et al. in 2014 reported that patients with UDT and a testicular atrophy index > 20 % had a significant increase in testicular volume after 5 years of follow-up when treated with pre- and postoperative GnRHa therapy [ 27].
This approval was based on a randomized Phase III trial published by Geyer et al 7 showing a longer time to progression in favor of the group receiving lapatinib.
Since then, a new randomized controlled trial published by Changulani et al. (2007) indicated that nails were superior to plates in the treatment of humeral shaft fractures.
An example of such situation is a multicenter PCR comparison trial published by Apfalter et al. [ 26], who sent the same atheromatous plaques to nine different laboratories for the detection of Chlamydia pneumoniae DNA.
Docetaxel 75 mg/m + cisplatin 75 mg/m + 5-FU 750 mg/m on days 1 5 every 3 weeks has recently become the standard of care in metastatic gastric tumors, and improved response rate, progression-free survival, and overall survival compared with cisplatin + 5-FU as the control treatment in a randomized Phase III trial published by Van Cutsem et al (Table 2).
In a 2001 single-center randomized controlled trial published by Rivers and colleagues, however, early goal-directed therapy (EGDT) versus standard therapy significantly lowered mortality (30.5 % versus 46.5%%) [ 7].
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