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And it's unacceptable that some scientists still consult people about a trial protocol only after it has been approved by a review board, when all involved are reluctant to revise it.
The assignment of the patient to a particular therapeutic strategy is not decided in advance by a trial protocol but falls within current practice and the prescription of the medicine is clearly separated from the decision to include the patient in the study.
The CancerGrid approach to software support for clinical trials is based on two principles: careful curation of semantic metadata about clinical observations, to enable subsequent data integration, and model-driven generation of trial-specific software artefacts from a trial protocol, to streamline the software development process.
This study provides preliminary evidence that a trial protocol with more complete details on the PRO endpoint may reduce the risk of avoidable missing PRO data.
This is a trial protocol.
The best place to do this is in a trial protocol or statistical analysis plan.
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On an average, treating a patient on a clinical trial protocol was associated with a TC saving of £4340.
To provide a concrete idea of our problem, the following is a snippet of a clinical trial protocol, downloaded from the clinical trials website http://www.clinicaltrials.gov, and modified for presentation as an example.
Each document d in our collection D is a clinical trial protocol which itself contains a set of eligibility criteria.
Unless a reliable source such as a comprehensive trial protocol is available, readers of trial reports should consider statements about subgroup prespecifications with scepticism.
In this way the interview study in itself becomes an indicator of the feasibility of a fundamental trial protocol component.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com