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Here, dropout and compliance rates in a feasibility crossover trial of tea are reported, and demographic and behavioral factors associated with study dropout and compliance are examined.
Strengths of this study include conduct of a four-arm crossover trial of tea that has not been previously reported.
Despite the fact that a number of biological, physiological and epidemiological field studies have provided evidence linking BT consumption and glucose metabolism, 16 17 22 42–44 51 52 a large-scale randomised controlled trial of tea consumption and diabetes risk would be useful to confirm these findings.
Although this discrepancy between laboratory and epidemiologic studies underscores the need for chemoprevention trials of tea, only a limited number of clinical trials have been conducted.
Although the washout periods included in the crossover trials of tea are a safeguard against carryover effects, lack of knowledge on the intensity and duration of carryover effects limits the utility of the washout periods.
The frequency, interval, and duration of the treatments were determined based on previous pilot trials of tea [ 5, 6].
Chemoprevention crossover trials of tea can be more efficient than parallel designs but the attrition and compliance rates with such trials are unknown.
Clinical trials of tea with more than two treatments should consider the use of the parallel design rather than the crossover design to decrease participant burden and increase compliance.
For these reasons multi-arm chemoprevention trials of tea might be more practical and achieve better compliance if conducted using the parallel group design rather than the crossover design.
Two YouTube pranksters are to go on trial over the theft of a cup of tea.
A cup of tea?
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