The phrase "a trial of first" is not correct in English and does not convey a clear meaning.
It seems to be an attempt to express something related to a trial or test, but it lacks clarity and proper structure.
Example: "The project was a trial of first, testing new methods in our research."
Alternatives: "a first trial" or "an initial test".
Jahanzeb et al (2002), in a trial of first-line vinorelbine and trastuzumab at the same schedule and doses as the current study, reported 78% of responses among 40 patients.
Since the addition of trastuzumab to anthracyclines resulted in high incidence of cardiac toxicity in the pivotal trial conducted by Slamon and colleagues, Baselga and colleagues conducted a trial of first-line nonpegylated liposomal doxorubicin plus trastuzumab and paclitaxel versus trastuzumab and paclitaxel alone in patients with HER2+ metastatic BC (Slamon et al. [ 1]; Baselga et al. [ 14]).
Our cross sectional methodology could not be used to provide information on whether patients were undergoing a trial of second alternative antipsychotic drug (switching) or not.
Patients who had responded to first-line hormonal therapy for <9 months were usually given chemotherapy on relapse, whereas those patients with longer response times were routinely given a trial of second-line hormonal therapy, including oral hydrocortisone, before chemotherapy was considered.
Their fate was also decreed by a trial of fire, the first world war, that would define their art for the rest of their lives.
A UK-based trial of first eye cataract surgery also reported that change in VRQOL after surgery was most strongly related to change in stereopsis, followed by contrast sensitivity [ 9].
Third-line agents, adjunctive therapies, as well as biological and alternative therapies may be useful when patients fail to respond to an optimal treatment trial of first- and second-line therapies used alone and in combination.
This is consistent with a clinical trial of first-line treatment with anthracyclines followed by a crossover to taxanes which showed reduced response to taxanes [ 17], suggesting that anthracycline treatment may induce taxane cross-resistance.
Mr. Williams was also found guilty in a separate trial of third-degree murder, which does not carry the death penalty, for the killing in January 1984 of Herbert Hamilton, 50, who had made sexual advances toward him, according to court testimony.
A large trial of second line antihypertensive treatments in patients already on low dose diuretics is required to provide a solid basis for treatment recommendations.
