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Ideally, harms and benefits of such identification should be tested within a trial framework, with provision of current "best practice" support.
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7 15 These studies have all been conducted within a clinical trial framework among depressed patients selected for their high suicide risk.
For example, further examination of validity, reliability, sensitivity, specificity, schizophrenic categories and assessment of cut-off scores for the Mini-PANSS can be examined in a clinical trial framework.
Our study was undertaken to attempt to find an optimal trial framework: minimizing the risk of bias, while taking feasibility into account.
The semistructured nature of the MEDIC-treatment enables individualisation of the treatment within the possibilities of a randomised controlled trial framework.
Thirdly, the treatment of the participants in this study following the preliminary assessment will be individualised within the possibilities of a randomised controlled trial framework.
To our knowledge this is the first report of an AKI biomarker study that used a development-validation approach with separate patient cohorts in the context of a large prospective multicenter trial framework.
The close adherence to a clinical trials framework is a strength of the current study (Kiluk et al., 2011).
107 108 In addition, the interpretation of trial results in published reports is not always consistent with the pre-specified trial framework, 6 109 110 especially among reports claiming post hoc equivalence based on a failure to demonstrate superiority rather than a specific test of equivalence.
Clinical evaluation of HIV vaccine candidates differs from the standard therapeutics trial framework primarily due to the fact that healthy individuals are studied.
The trial framework is to detect superiority of MRE over USS.
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