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The phrase "a tremendous setback when" is correct and usable in written English.
It can be used to describe a significant obstacle or difficulty that occurs at a specific point in time or under certain circumstances.
Example: "The project faced a tremendous setback when the main supplier went out of business unexpectedly."
Alternatives: "a significant obstacle when" or "a major hindrance when".
Exact(1)
Last November, after years of rolling smoothly toward anticipated certification, production and delivery of its first aircraft this year, Eclipse suffered a tremendous setback when the lightweight engines to be produced for the jets by Williams International failed to meet requirements.
Similar(59)
Governor Arnold Schwarzenegger clearly had it in mind when he recently said "Last year we had a tremendous setback because some of the science and some of the numbers were manipulated and that is very damaging because it gives the other side a way in".
"I believe that this is a tremendous setback for North Korea and, indeed, a setback for the world," Trump said.
"If Novartis had won, this would have been a tremendous setback for us," he said.
From the Times: "This is a tremendous setback," said Steve Valk, communications director for the Citizens Climate Lobby, an advocacy group devoted to enacting a carbon tax in the United States.
That would be a tremendous setback to a program that has proven beneficial to tens of thousands of children across the state.
Even after the team had left, the British Deputy High Commissioner complained that the incident had caused a "tremendous setback" in relations between the two nations.
"If the Kaesong project is stopped and we have to pull our workers completely, it will be a tremendous setback to South-North relations," Unification Minister Ryoo Kihl-jae of South Korea said during a parliamentary hearing.
"It is a tremendous setback.
The bill is unconstitutional and, if passed, would signify a tremendous setback for women's land rights.
There's also the effort to re-elect New Jersey Gov. Jon Corzine -- for without him, the effort to secure marriage equality there will suffer a tremendous setback.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com