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The phrase "a tremendous difference of" is correct and usable in written English.
It can be used when discussing a significant disparity or variation between two or more things.
Example: "There is a tremendous difference of opinion on how to address climate change among experts in the field."
Alternatives: "a significant difference in" or "a vast difference between".
Exact(1)
With a view of expecting similar survival but a tremendous difference of adverse events between treatment alternatives, valid data on health-related quality of life could tip the balance.
Similar(59)
A little practice can make a tremendous difference on the type of impression you make and how lasting it is.
Mr. Stein's devotion and ongoing investment in North Shore-LIJ over the years has made a tremendous difference to thousands of patients and their families.
UNICEF is also advocating for free primary education, which would make a tremendous difference for thousands of children like Susannah.
Because everyone in the show, not only the boldface names, make a tremendous difference to my enjoyment of a show.
A physician's attention, warmth, caring, concern, and practical assistance, as well as accurate and open communication, can make a tremendous difference to the health of older patients.
It makes a tremendous difference to people.
"This will make a tremendous difference because tens of thousands of young people — predominately young people of color — will not be run through the system as criminals," said Steven Banks, the attorney in chief at the Legal Aid Society, which has handled thousands of the cases.
In contrast, when dealing with long-read datasets with varying read lengths, the situation showed a tremendous difference in percentage of total multimapped reads and correctly mapped multimapped reads.
But this was an opportunity that I felt was a once in a lifetime chance to make a tremendous difference in the lives of millions of children and I simply could not pass it up... Laurie Rubiner.
And it makes a tremendous difference in their awareness of the physical aspects of music". He also wants his students -- and all young pianists -- to consider what happened to him when thinking about their careers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com