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The phrase "a tremendous difference in" is correct and usable in written English.
It can be used when discussing the extent of variation or change between two or more things.
Example: "There is a tremendous difference in the quality of service between the two hotels."
Alternatives: "a significant difference in" or "a vast difference in".
Exact(60)
Though it was not statistically significant, there was a tremendous difference in the level of self-assessment between different age groups.
It can make a tremendous difference in the saving and improvement of other people's lives.
"I made a tremendous difference in our country," he said, citing himself.
"We've seen posing make a tremendous difference in people's presentation and performance," he said.
Other matters, though, retreat to the background, and that unfortunately makes a tremendous difference in understanding war — particularly this war.
But he added that Dr. Thurston's work had made "a tremendous difference in the way we look at many problems".
As this paper will demonstrate, however, understanding the reasons behind human food preferences can make a tremendous difference in the well-being of the world's people.
For many people, even a small amount of flexibility can make a tremendous difference in successfully harmonizing responsibilities at work and at home.
You've heard me say many times over, and I absolutely believe it, that his leadership made a tremendous difference in our nation.
They came from South Carolina where the cotton stalks were bare.... [But] there was a tremendous difference in the way life was lived up North.
"When a team displays the kind of commitment we did, it makes a tremendous difference in the outcome of the game".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com