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The phrase "a tremendous difference between" is correct and usable in written English.
It can be used to highlight a significant distinction or contrast between two or more things.
Example: "There is a tremendous difference between working in an office and working remotely."
Alternatives: "a significant difference between" or "a vast difference between".
Exact(13)
There's a tremendous difference between alone and lonely.
There is a tremendous difference between tennis and basketball.
There's a tremendous difference between the two questions: 1) Why do human beings make the judgments of right and wrong that they do?; and 2) Are these judgments correct?
But for policy purposes, there is a tremendous difference between a tracking ecosystem that is anonymous and a tracking ecosystem that is suffused with identity but promises to ignore it.
But we can also detect a tremendous difference between Hume's understanding of human capacities and that of Kraus: the author of Amo's dedicatory letter doesn't even consider the possibility of anchoring what individual human beings are capable of doing to something as arbitrary as "complection".
There's obviously a tremendous difference between institutions like Wisconsin and Amherst – the integration of athletics at the Division III level is wholly different than on the Division I level.
Similar(47)
"There is a tremendous difference in price between co-ops, where you own shares in a building, and condos, which is like owning your own house in a building," Ms. Holzman said.
With a view of expecting similar survival but a tremendous difference of adverse events between treatment alternatives, valid data on health-related quality of life could tip the balance.
Though it was not statistically significant, there was a tremendous difference in the level of self-assessment between different age groups.
Cover cropping, planting grasses and legumes that fix nitrogen between cash crops, can make a tremendous difference in soil, according to studies by Dr. Brennan.
This compromise between antique and modern timbres makes a tremendous difference.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com