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Overall, this lack of perturbation of metabolism until 48 hours suggests higher resistance of the OCSCs to docetaxel at a treatment level to which OCCs respond.
It is important to note that the clinician should consider all agents in a treatment level before proceeding to "lower" level.
Finally, a glycemia measure such as glycemic burden that accounts for the time and extent to which a treatment level is exceeded is intuitively appealing but difficult to calculate.
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This is true when treatment is not used in the second wave (Fig. 11(a)), treatment levels are low (Fig. 11(b)) and when treatment levels are high (Fig. 11(c)).
The individual costs of interventions are listed in Appendix 7. A treatment-level perspective of costs was taken for the analysis.
For a moderate treatment level (40%), the resistant strain with HTF will gain a competitive advantage for low values of R0, which requires a significantly larger stockpile compared to the scenario in which resistance is absent.
This study investigated the tolerance of Penaeus (Marsupenaeus) japonicus embryos to ozone disinfection to establish a suitable treatment level that has no detrimental effect on embryo hatch rate.
We simulated the model by considering a constant treatment level throughout the outbreak.
For a low treatment level (20%), the profiles of antiviral courses are virtually identical in both scenarios, as the prevalence of resistance is negligible.
However, disease containment may be achieved for low values of R0 when resistance is absent, as illustrated in Figure 4c (solid curve) for a 60% treatment level.
They were, however, recommended as a first-line (Level A) treatment for premature ejaculation [ 58, 59].
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