Exact(2)
Are there divergent mechanisms in early RA and late RA, and is there a transient window for curing the disease with aggressive therapy?
This indicates that cancer cells that have detached from the extracellular matrix might go through a transient window where they can be killed by compounds such as Navitoclax or ABT-199, which would give anti-metastatic properties to these agents.
Similar(58)
Many questions, such as why there is only a transient 'normalization window' and how to identify it, remain unanswered.
From qPCR analysis, we estimated that the ZC3HAV1L-CHMP1A chimeRNA RNA is present at ~ 0.1 copies per HMLE cell, suggesting that its expression is limited to either a small population of cells, or a transient time window.
It has recently been demonstrated that anti-angiogenic agents are likely to work through a process of normalisation of vasculature wherein leaky tortuous vessels in tumours are 'normalised' and excess vessels pruned, resulting in a reduction of interstitial fluid pressure during a transient 'normalisation window' (Tong et al, 2004; Willett et al, 2004).
One hypothesis is that these cells show a transient developmental window during which they respond similarly to any event (Aimone et al., 2006), but, upon maturation, they become a population of granule cells that are activated only upon re-exposure to experiences similar to those that occurred during their development (Tashiro et al., 2007; Aimone et al., 2009).
This presumably transient window of hypersensitivity is particularly worrisome in individuals with preexisting cardiovascular disease who are already burdened by a reduced capacity for compensation.
The role of critical periods of sensitivity as transient windows for opportunistic therapies for behavioral teratology is discussed.
Here, we find that local rEPO administration induces a significant proangiogenic effect and a transient stimulation of tumor growth in window chambers.
We hypothesized that this could not be accomplished in the 2-3 day time window provided by a transient transfection experiment.
Accordingly, we develop a transient therapeutic strategy during a neonatal window, which prevents cerebellar developmental defects and provides long-term benefits on motor functions.
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