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Furthermore, when used as single agents, combretastatins induce only a transient shutdown of tumour blood vessels and do not cure cancer (Heath and Bicknell, 2009).
Excess iodide is well known for this Wolff-Chaikoff effect, which is associated with a transient "shutdown" in the thyroid gland (Wolff and Chaikoff 1948).
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Among these features is the phosphorylation and inactivation of translation initiation factor 2 α (eIF2 α), which causes a prominent, yet transient, shutdown of general protein synthesis (Pyrko et al, 2007a, 2007b).
One branch of the UPR, mediated by protein kinase RNA (PKR -like/Pancreatic ER kinase (PKR -like/PancreatictransiERt shutdown of protein synthesis.
The PERK-eIF2α branch of the Unfolded Protein Response (UPR) mediates the transient shutdown of translation in response to rising levels of misfolded proteins in the endoplasmic reticulum.
This is because Insulin receptors are not degraded, therefore the only way to achieve a transient signal is via the SOS feedback loop to shutdown the Ras pathway.
In our model, receptor degradation is now essential because there is no negative feedback loop present on the C3G/Rap1/B-Raf pathway so the signal has to be shutdown at the receptor level to achieve a transient response, which makes the process of receptor degradation essential.
A transient.
It was a transient annoyance.
In the case of a transient, the passive residual heat removal system (PRHRS) is designed to cool the reactor coolant system (RCS) from a normal operation condition to a hot shutdown condition by a natural circulation, and the shutdown cooling system (SCS) is designed to cool the primary system from a hot shutdown condition to a refueling condition by a forced circulation.
"They're a transient community.
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