The first phase is host penetration by cercaria, which is usually manifested as a transient (hours) itchy eruption that occurs soon after exposure and is known as swimmer's itch or cercarial dermatitis.
This analysis also showed that both cell types underwent apoptosis in response to either a transient (three hour pulse) or prolonged treatment (24 hours) with cytarabine (detected as cells with a subG1 DNA content in Figure 2B).
Schirmer et al.[ 32] found a transient 24-hour survival benefit in a rat model of septic shock.
This was particularly evident for Cyp2B10, a sensitive and responsive CAR target, which showed a transient induction 4 hours after the bile acid peak.
According this model the concentration of drug can decrease 50% at a distance of three cells from tumor-host interface in steady-state and up to 80% across the same distance in a transient of 2 hours.
Strikingly, the patterns of mRNA accumulations were different from those of proteins with a transient induction by 1 hour post-stimulation followed by a rapid return to basal level.
In contrast, the concentration of PMN, after a transient decrease the first hour after exercise, increases as cells are released from the bone marrow reserve, and stay high for several hours [ 6, 7].
This indicates an early decrease in the expression of pro-apoptotic genes, followed by a transient up-regulation 24 hours after surgery and then returning to basal expression after 48 hours.
In contrast IRF-1 protein level showed a transient increase after 3 hours of TNFα treatment and declined thereafter (Fig. 1B).
Within post-exposure periods up to 48 hours, a transient kinetic response was observed at lower CS doses, whereas higher doses resulted in more sustained responses.
The cytokines IL-1α, IL-6, TNFα, IL-10, interferon-γ and CXCL1 were all measured and did not change at any time point, apart from CXCL1, which showed a transient increase at 3 hours (Fig. 5A).
