This preference, which is graphically illustrated in Figure 4, might be related to a transcriptional function of the initiator or a translational function of the TOP or to both functions.
As with ARG80, this interaction may be due to a transcriptional function of Pif1.
This compound binds and stabilizes a particular p53 mutant, Y220C, and restores its transcriptional functions to that of the WT protein (Liu et al., 2013).
Table 4 lists candidate genes that may have a transcriptional function in either permitting or abrogating metastasis.
Meanwhile, stromal cells also induce NOTCH3 activation in BrCa cells, which exert transcriptional functions to stimulate NOTCH target genes that are simultaneously facilitated by the activated STAT1.
The ΔN-isoform of p53 recently reported [ 27, 28] or ΔN-isoforms of p63 and p73 (all lacking the transactivation domain) might modulate an imbalance between them and full-length p53 leading to an altered transcriptional function of p53 and in turn to an acceleration of the ageing process [ 30, 31].
Moreover, mammalian HDAC1 is also sumoylated, and sumoylation of the EGF/RTK/Ras-responsive ETS transcription factor Elk-1 confers a Class I-HDAC-dependent transcriptional repressor function to Elk-1 [ 19].
In order to see whether KlROX1 has a transcriptional repression function similar to that of the S. cerevisiae ROX1, a Δklrox1 null mutant was constructed and used in the investigation of oxygen response in K. lactis.
Gal4-FF may be too weak a transcriptional activator to function in the context of a highly stringent gene trap requiring a translational fusion with the N terminus of the protein encoded by the mutated gene.
Besides regulating motile cilia biogenesis, Foxj1 also has been suggested to have a non-ciliary transcriptional function in mammalian lymphocytes (Lin et al., 2004).
