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The phrase "a tough dose" is correct and usable in written English
It can be used to describe a difficult or harsh experience, often in the context of receiving bad news or facing a challenging situation. Example: "Hearing that I didn't get the job was a tough dose to swallow, but I know I need to keep trying."
Exact(3)
When I was 5, I got a tough dose of reality from my friend Mark.
Some years before the 2010 general election, when he was the shadow education secretary, David Willetts delivered a tough dose of realism to his fellow Conservatives.
"To make up that figure it is suggesting cuts among the health trusts totalling £113m, cuts to prescribing medication and some family services of around £20m, while the department and arms length bodies such as the fire service will be expected to provide savings of around £31m, so it is a tough dose of savings," she added.
Similar(57)
However, proper combinations and doses is a tough issue to be resolved.
That is a tough matchup for the Patriots, too, so expect another heavy dose of Torrey Smith and Jacoby Jones.
"A tough, tough group".
"This was such a tough, tough series.
It's a tough, tough case.
"It's a tough, tough deal.
"I learned a tough lesson, very tough.
"It was a tough, tough summer.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com