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The phrase "a topic of substantial" is correct and usable in written English.
It can be used when discussing a subject that is significant or important in a particular context.
Example: "The research paper focuses on a topic of substantial interest in the field of environmental science."
Alternatives: "a matter of considerable" or "an issue of significant".
Exact(8)
Tear proteomics in keratoconus has been a topic of substantial discussion and speculation over many years.
Calculating relative free energies is a topic of substantial interest and has many applications including solvation and binding free energies, which are used in computational drug discovery.
Although Mental Health Literacy (MHL) has been a topic of substantial interest, measurement of this concept using a scale-based measure has been limited, including a lack of psychometric and methodologically robust scale-based measures of MHL.
The use of the DMT in real clinical practice setting has been a topic of substantial debate for payers at hospital and CCAA level.
Health workers' motivation has emerged as a topic of substantial interest in this context.
The definition of a successful IS has become a topic of substantial research and debate [ 3- 7].
Similar(52)
Although the substantial contribution of non-analytic reasoning to the diagnostic process is obvious, it is a topic of debate whether this kind of reasoning can be taught.
It's a topic of conversation".
Amazingly, this is a topic of debate.
It's a topic of concern".
Choose a topic of study.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com