The phrase "a too stringent" is not correct in English.
The correct form would be "too stringent" without the article "a."
Example: "The regulations are too stringent for small businesses to comply with."
Alternatives: "excessively strict" or "overly rigid."
This is probably a too stringent criteria compared with the study performed on yeast protein-protein interaction networks [36], where the shortest path between disconnected nodes were treated a large number instead of infinity.
A too stringent cutoff may run the risk of missing out many true disease susceptibility loci (DSL) with only moderate p-values for association while one too loose may introduce too many noises.
Similarly, sequences longer than the average length due to insertions will be subjected to a too stringent threshold which may lead to false negative species resolution (Type II error).
This "dynamic" enrichment detection approach overcomes the limitations of a more commonly used "selection" approach where a too stringent cutoff might lead to potential loss of significant information, and a too relaxed cutoff might include insignificant data into the evaluation [20].
A too stringent search strategy seems the most likely cause.
However, a too stringent parameter reduction should be avoided since selecting too low a rank can lead to biased estimates of genetic parameters [ 14, 15].
Six months appeared to us to offer the best balance between including long-standing cases for which it would be difficult to assess prior risk factors and excluding too many new cases that would otherwise be excluded with a too-stringent definition of time between initial symptoms and codes.
Finally, multifunctionality ranking may be a too-stringent control (when using ROC) because it is literally optimized and performs better than many real algorithms on actual data ; rather, the correlation of the "real" prediction results with multifunctionality ranking is often a more helpful measure.
First, strict separation of treated and control samples in a heat map might be a criterion too stringent for a qualifying classifier.
"If I remember correctly, she came in and she said that she felt that she hadn't been fair to the process and her standard, or something to that effect, was a little too stringent," Ms. McWilliams said.
