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For most of the experiments a concentration of 1 1015 was used because it results in single molecules separated by several μm, whereas the 1 1014 diluted sample shows a too dense concentration for our automated peak-finding routine.
Ligand clustering may in fact favor the formation of multivalent interactions, but a too dense arrangement of the ligands can also lead to weakened binding owing to steric effects, as previously reported for cholera toxin binding to GM1. 28 For 20 % GalCer domains, however, there was no correlation in binding between the VLPs and the edges of larger gel-phase domains.
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The only disappointment at dessert time was the gluten-free brownie sundae, which had a too-dense, fudgelike texture.
And a few of the desserts disappointed, including a too-dense molten chocolate cake and a dry chocolate macadamia nut pie on special one night.
Several desserts were underwhelming, especially the tarte Tatin, whose bottom pastry layer was scorched black, and the Rive pain perdu, a too-dense bread pudding.
And Orissa's unusual dessert menu — which includes delicious takes on Indian favorites like kulfi ice cream and kheer pudding— misfires with a bland, mushy apple tart and a too-dense spiced chocolate cake.
Everything here is a little too saturated, a little too bright, a little too dense.
He has a biography too dense to summarise.
The coconut flan was also sweetly satisfying, if a tad too dense for my taste.
"The fruit is a little too dense, and there isn't as much of it".
(Despite its savvy writing "Community" on NBC is probably a hair too dense to fit this bill).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com