First, C hybridizes with the inhibitory strand within Sp-I, which allows the aptamer to bind DFHBI and become fluorescent while concomitantly exposing a short toehold sequence.
If you hang in there though, eventually you are rewarded with the kind of puzzle that is tough to gain a toehold in, but allows you to snake your way through the grid to completion.
American diplomacy in Pakistan and India this month has produced a tiny victory for each side in the struggle over Kashmir, a toehold on which to proceed.
The input strand initially displaces the internal inhibitory strand to activate the fluorescent aptamer while exposing a toehold to which the fuel strand can bind to further displace and recycle the input strand.
Nonetheless, Western oil companies are lining up to get a toehold in Saudi Arabia, which nationalized foreign oil holdings in the 1970's.
This included Sen. Elizabeth Warren (D-Mass)., who explained her action by saying that Carson "made good, detailed promises" that serve as a "toehold on accountability," which Warren committed herself to pursue personally.
Despite all the difficulties, some foreigners remain interested in gaining a toehold in a market from which American rivals are banned, and which is likely to open up once Mr Castro is gone.
If this government falls, we're going to have a patchwork of forces, dominated by the Shabaab, which will provide a toehold to Al Qaeda and other foreign fighters.
They initially barracked against foreign retailers' being allowed a toehold in India, for example.
This exposes an additional toehold, to which the fuel strand binds, releasing the output strand 2. The fuel strand further displaces the input strand, and the double-stranded product is waste that does not further react.
