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The Tie2-Cre Nrp1 fl/- mutants are embryonic lethal and finding a tissue with an adequate source of cells was of paramount importance.
The differences in gene expression following treatment of a tissue with an active compound was monitored using two libraries of wound tissue derived from control (phosphate buffer saline, PBS, normally healing) and dexamethasone (DEX, badly healing) treated mice.
Consequently, muscle is one of the best examples of a tissue with an inherent adaptation capacity to sustain not only locomotion but also a number of life-sustaining processes [ 15].
For example, when using the low-field imaging setup demonstrated in Figure 3C, if 1 mM concentration of proton spins with PH = 0.01 (1%) is achieved in a tissue with an imaging voxel size of 10 mm, one should expect a SNR of 23.
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Bone is a tissue with a strong regenerative potential.
To elucidate the role of pH fronts and damage in GET efficiency we present an analysis of the pH fronts-tissue natural buffer interaction through a theoretical model using the Nernst-Planck equations for ion transport assuming a tissue with a bicarbonate buffering system and its validation with experimental measurements.
Comparison of a tissue with a cell line provides a rich source of differentially expressed transcripts but may not adequately reflect the issues faced with systems of greater biological interest.
In bone, a tissue with a remarkable repair potential, such responses appear suppressed, probably by persistent inflammation [ 6].
Skin is a tissue with a high vascularity and thus, this system using immunodeficient mice and human tumour cells allows a very accurate assessment of tumour angiogenesis.
Interestingly, transcripts for OsCDC20_2 and OsCDC20_3 were detected in inflorescence, a tissue with a high rate of proliferation, suggesting their involvement in mitotic activities [ 67].
The overall conclusion from the different experimental approaches used is that the phloem unexpectedly represents a tissue with a highly active AsA biosynthetic capacity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com