Patients' health status (age and complexity of treatment) explain a part of the reluctance to substitute an original formulation by a generic, but this uncontrollable determinant is responsible for only a tiny part of substitution rate variations.
Among them are her letters and personal records (she sometimes substituted a tiny painted violet for her signature) and the elaborately appointed, tiered boxes containing her fishing tackle, sewing and needlepoint materials, medicines and art supplies.
Having corners instead of rounded edges, a tiny house is expensive to tow; it is not a practical substitute for a mobile home.
A tiny minority of downloaders treat the free e-book as a substitute for the printed book those are the lost sales.
Others have followed, including Munich Re and a tiny U.S. company called XL Re. "The role of reinsurance as a substitute for capital is not well understood," says Kielholz.
If you don't own pastry bag with tips, you can snip a tiny corner out of a plastic resealable bag to use as a substitute for a pastry bag.
I asked if she could substitute the reward of sugar for something else – a walk, a tea, a tiny purchase, something obviously shit compared a Crunchie?
