Drug companies and regulators can never hope to scrutinize even a tiny fraction of every combination of disease, drug and patient-specific genes that might be medically important.
As a result, only a tiny fraction of all possible combinations can be experimentally tested, and of those only a handful of combinations have well-understood mechanisms elucidated from clinical experience.
The composition and particular arrangement of amino acids in proteins confers the distinct biochemical functionality, but it remains unclear why only a tiny proportion of possible character combinations are potentially functional.
Nearby on a long table were bowls of olives, a plate of goat cheese and a tiny cup of za'atar, the Middle Eastern spice combination of hyssop, sesame seeds and sumac.
Combo skin-A combination of either.
A crowd is amassing outside Mambo Wine & Dine – an all-ages combination of tiny Geordie boys perched on bikes, trying to get a look; photographers both amateur and not in bodywarmers and holding DSLRs, trying to get a press shot; pre-teen girls eating sweets; mums and older sisters, arms huddled against the wind, cheerfully Snapchatting every moment of anticipation.
To test it, Plankton lets SpongeBob taste a fruitcake, but he is immune to jerktonium because of a combination of his tiny brain and his big heart.
It is therefore certain that only a tiny fraction of the potentially possible chromosome and gene combinations can ever be realized.
At Syrrx, a structural genomics company, a robot places a tiny drop of protein into 480 wells, each containing a different chemical combination.
We've got a good dietician in town and he sits down and talks to them with a combination of regular exercise program and diet and only a tiny percentage of people lose weight.
