But with "Red Beard," an especially arduous and time-consuming production, Mifune and Kurosawa came to a parting of ways after 17 years.
Despite this success, a number of limitations have been highlighted with these vectors including time-consuming production, uncertain reproducibility, limited carrying capacity of transgenes, safety concerns such as toxicity, dose-dependent immunogenicity and potential integration into the host genome causing oncogene activation [36, 72].
In a reversal of the traditional pattern in which Korean manufacturers often copied popular Japanese products at lower cost, competitors in Japan, using cheaper and less time-consuming production methods, are homing in on South Korea's biggest kimchi export market.
Manufacturers have been scrounging for spare supplies, but they have already shipped 95percentt of their run for this year, and because of archaic and time-consuming production methods they don't have time to make more.
Nevertheless, the use of viral gene carriers is limited by costly and time-consuming production, restricted cloning capacity, and most important severe immune responses [ 3, 6].
But movies were expensive, time-consuming productions that required multiple sets and locations.
A single intermediate energy cyclotron may easily cover regional needs, so implementing a time-consuming, solid, enriched target 67Ga production process on a small medical cyclotron has little economical justification.
Digital printing has facilitated production, but creating a good print is still a time-consuming process.
Reloading is a time-consuming operation.
