The phrase "a time when mice" is correct and usable in written English.
It can be used in contexts discussing specific events or situations involving mice, whether literal or metaphorical.
Example: "There was a time when mice roamed freely in the fields, unbothered by human presence."
Alternatives: "an era when mice" or "a period when mice".
Of note, the difference in RQ between AOiGHD and GH-intact mice was most prominent during the evening hours when mice are actively feeding, while mean values for each group steadily converged throughout the day, a time when mice are sleeping (voluntary 'fast'fast
Using deficient mice or depleting antibodies, we observed that CD8+ T cells and IFN-γ drive the rapid increase in total parasite biomass and accumulation of IRBC in the brain and in different organs 6 12 days post-infection, at a time when mice develop ECM.
One caveat is that the mice used to generate these transcriptomic data sets were 3 6 months old (a time when mice are still growing), whereas the humans donors averaged ~55 years of age, meaning that some of the gene expression differences can be ascribed to relative age differences.
Female mice (WT, C1qa−/− and C3−/−) pre-treated with intranasal peptide before being grafted with syngeneic male skin (from WT, C1qa−/− and C3−/− donors, respectively) were boosted (intraperitoneally) with syngeneic male splenocytes 12 wk after grafting, at a time when mice in the WT group were tolerant of their skin grafts, whereas the complement-deficient mice had rejected theirs (see Fig. 2).
Moreover, E-box genes are expressed primarily during the light period (Rey et al., 2011), when mice normally eat little, and suppression of these genes is similar to the expression level of these genes at night, a time when mice consume the most food.
In conclusion, we have shown that CD8+ T cells and IFN-γ mediate IRBC accumulation in the brain and in other organs during ECM at the time when mice develop clinical signs.
The time of disease onset was determined by the time when mice began to fail the rotarod test.
Meal size increased over the day, the whole dark phase and scheduled feeding time when mice had scheduled access to HFD (SNK; P = 0.023, P < 0.05 and P < 0.001 versus baseline during adaptation; P = 0.005, P < 0.05 and P < 0.001 versus baseline during habituation; P < 0.001, P < 0.05 and P < 0.001 versus baseline during refeeding).
Removal of SMN at 1 month postnatally in the SMA Δ7 mouse results in no impairment in synaptic transmission at NMJs, 1 month later, at a time when the mice are dying (Le et al, 2011).
Of note, we have also started treatment at a time when SOD1 mice already display clear electromyographic denervation signs.
Remarkably, anle138b preserves learning and memory at a time, when untreated mice become terminally ill, which points to a longer disease-free survival accompanied with unimpaired cognition.
