MC-RR content in kidney of crucian carp showed a time dose-dependent increase within 48 h post-injection, followed by a sharp decline afterward, while no MC-LR in kidney was detectable throughout the experiment.
Surprisingly, we found that extracellular ATP levels were lower in supernatants derived from post-hypoxic endothelia in a time-dose dependent fashion, suggesting that endothelial ATP release is attenuated by hypoxia (Figure 1B).
In summary, we have demonstrated that gastrin induces mcl-1 protein expression in AGS-GR cells in a time-, dose-, and CCK-2-dependent manner (Fig. 1).
In these models, sorbitol promoted the phenotypic manifestations of early apoptosis followed by complete loss of viability in a time-, dose-, and cell type-specific fashion, by eliciting distinct yet partially overlapping molecular pathways.
We also showed that 17-AAG is able to reduce the percentage of macrophage infection and the parasite burden in a time-dose dependent manner with an EC50 of 149 ± 7 nM.
HFMSE scores indicated an improvement in motor function at all doses levels, with a time and dose dependency.
A time and dose dependent biofilm degradation is observed for φ15 infection of PpG1 biofilms initially grown for 24 h.
rmANOVA showed a time × dose interaction for change in body weight (F 6,68) = 24.9; P < 0.001; ε = 0.95).
Figure 4A demonstrates a time and dose dependent loss of protein expression in treated cells.
While UV index is instantaneous value, SDD is a time accumulated dose.
A time and dose effect was observed, with cell viability undergoing a significant (P < 0.05) decrease with extract concentration.
