Incubation of these compounds with Mdm4 under nonreducing conditions lead to a time dependent change of Mdm4 structure determined by NMR; concomitantly, the MS analysis showed the presence of covalent adducts of the compound with Mdm4.
The results revealed a time-dependent changes of the autophagic markers, including accumulation of LC3-II and degradation of p62.
A time-dependent change of phase of SAW and change of insertion loss (change of amplitude) were observed when the cells were treated with 0.5 or 1.0 mM H2O2.
We observed that the incubation of MSC with a conditioned medium prepared from chemically damaged but not undamaged muscle resulted in a time-dependent change from fibroblast-like into elongated multinucleated cells, a transient increase in the number of MyoD positive cells, and the subsequent onset of myogenin, α-actinin, and myosin heavy chain expression.
As such, future studies that allow a time-dependent change in the model should be explored.
There was a 2.2-fold increase in luciferase activity when cells were co-transfected with anti-miR-26b (Fig. 6a) and similarly, a time-dependent change in luciferase activity in response to HU treatment, with the highest luciferase activity observed after 12 h of HU treatment.
We observed a time-dependent change in the gain characterised by a significant increase during phenylephrine and a significant decrease under nitroprusside.
This requirement is not met for instance if vibrational cooling leads to a time-dependent change of a vibrational frequency, in which case this would need to be modelled explicitly [30] [32].
Thus, the T-cell repertoire appears to show a time-dependent change following immunization.
A time-dependent change in conduit and resistance artery endothelial function is found in the coronary circulation.
Acetylation levels of p53 were observed to undergo a time-dependent change as shown in Figure 6e.
