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Incubation of these compounds with Mdm4 under nonreducing conditions lead to a time dependent change of Mdm4 structure determined by NMR; concomitantly, the MS analysis showed the presence of covalent adducts of the compound with Mdm4.
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As such, future studies that allow a time-dependent change in the model should be explored.
A time-dependent change of phase of SAW and change of insertion loss (change of amplitude) were observed when the cells were treated with 0.5 or 1.0 mM H2O2.
There was a 2.2-fold increase in luciferase activity when cells were co-transfected with anti-miR-26b (Fig. 6a) and similarly, a time-dependent change in luciferase activity in response to HU treatment, with the highest luciferase activity observed after 12 h of HU treatment.
We observed that the incubation of MSC with a conditioned medium prepared from chemically damaged but not undamaged muscle resulted in a time-dependent change from fibroblast-like into elongated multinucleated cells, a transient increase in the number of MyoD positive cells, and the subsequent onset of myogenin, α-actinin, and myosin heavy chain expression.
We observed a time-dependent change in the gain characterised by a significant increase during phenylephrine and a significant decrease under nitroprusside.
This requirement is not met for instance if vibrational cooling leads to a time-dependent change of a vibrational frequency, in which case this would need to be modelled explicitly [30] [32].
Thus, the T-cell repertoire appears to show a time-dependent change following immunization.
Acetylation levels of p53 were observed to undergo a time-dependent change as shown in Figure 6e.
A time-dependent change in conduit and resistance artery endothelial function is found in the coronary circulation.
A limitation is our single post-exercise assessment of cTnI, as previous observations reported a time-dependent change in cTnI after a marathon (Middleton et al. 2008).
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