The phrase "a tiling approach" is correct and usable in written English.
It can be used in contexts related to design, architecture, or problem-solving strategies that involve arranging elements in a tiled manner.
Example: "In our project, we decided to implement a tiling approach to optimize the layout of the user interface."
Alternatives: "a grid method" or "a mosaic technique".
The target genome size and the feature number available, combined with the biological question asked, will decide whether a tiling approach with equidistantly distributed probes of the entire genome is possible or not.
Hains et al. proposed using a tiling approach to improve the performance of the intratask kernel of CUDASW++ [ 25].
Given user-supplied chromosomal coordinates, and a desirable size range for the southern blot probe (default 500-1300 bp), we used a tiling approach to generate many possible probes in the specified design window.
Tiling Assembly is a heuristic, ab initio transcript assembly algorithm, which uses a read tiling approach to identify transcripts.
Using a two-step tiling approach, we systematically screened U7 snRNAs carrying splice-switching SSO sequences targeted to the cryptic 5′ splice site created by HbE mutation.
We still consider "selective tiling" better than a plain equidistant tiling approach, as high or low affinity probes would have to be heavily adjusted or thrown away during background predictions or normalisation procedures anyway.
If a more selective tiling approach is used, as described in this paper, it should be possible to choose a set of probes that are more homogeneous, reducing the noise that is otherwise introduced by significant probe-affinity differences.
This was assessed in human cells using multiple pairs of primers in a RT-PCR-based tiling approach (Figure 1A), which revealed a novel SIRT1 transcript skipping precisely the 558 bp of Exon8 only, to produce an Exon7/9 splice junction (Figures 1A and S1), as confirmed by sequencing the RT-PCR products (data not shown).
The main steps of s2m method will be described with a focus on the tiling approach.
In a series of initial calibration experiments we demonstrate how the barcode tiling approach can quantify the abundance of individual template molecules from a pool of 305 shRNA expression constructs.
Nonetheless, there is a noteworthy unsolved issue associated with local-based analysis in the tiling approach, namely the selection of the size of the local relevant regions [2].
