During VOR-increase training, there was a tight, trial-by-trial correlation between the activity of the climbing fiber input to a given Purkinje cell and the induction of changes in its simple-spike output.
Moreover, during a smooth pursuit oculomotor learning task, there is a tight, trial-by-trial correlation between the occurrence of individual spikes in a climbing fiber and changes in cerebellar output on the subsequent trial, suggesting that climbing fiber spikes provide a potent and reliable trigger for plasticity (Medina and Lisberger, 2008; Yang and Lisberger, 2010, 2013).
A tight efficacy trial, focusing intensely on both glycemic control and on side effects, and which could be the basis for larger studies, possibly observational, in real life settings, is badly needed.
DOI: http://dx.doi.org/10.7554/eLife.02076.007 The tight, trial-by-trial correlation between the occurrence of a climbing fiber spike on one trial, and the change in Purkinje cell simple spike output on the next trial suggests that the activation of the climbing fibers is what is triggering the changes in Purkinje cell output during VOR-increase training.
In that case, Mr. Hun Sen could keep a tight reign on any trial.
Jurors' identities are being kept a tight secret, even from the trial lawyers.
More than 200 journalists have signed up to cover the trial and a tight blanket of security will be enforced by federal, state and local police in and around the courthouse in this town near Orlando in central Florida.
We should remind that some evidence on triptan preference in clinical practice does exist, even if we recognize that a tighter link between trials and clinical practice might be developed, for instance, by appropriate surveys [6, 7].
This assumption cannot be verified using the presented data but the detected association between impaired AR and SAD further supports the need for trials investigating whether a tight control of arterial blood pressure, avoiding hypo- and hypertension during the first days of sepsis, could reduce the incidence of SAD.
It had completed mid-stage trials, but had shelved the drug due to a tight budget.
