Effector T cell functions are under a tight control of a specialized T cell subset, regulatory T cells (Treg).
Since many of the effects of IL-6 are mediated through activation of protein phosphorylation cascades, this implies that Twist expression must be under a tight control at the post-translational level in order to respond in a timely manner to external stimuli.
As a consequence, we suggest that diabetic heart failure patients should receive appropriate doses of ACEi/ARB and/or aldosterone receptor blockers under a tight control of potassium and renal function markers, rather than withholding these potentially life-saving drugs.
In this scenario, it is likely that the activity of molecules like TRPM2, an ion channel member of the transient receptor potential (TRP) superfamily, that is able to mediate cell death upon increased oxidative stress [ 2], needs to be kept under a tight control in malignant cells as well.
One obvious explanation is that RHOBTB3 and LIMD1 exert a tight control on the levels of HIF1α under normoxic condition, which is eased up in hypoxia to allow for appropriate HIFα accumulation.
Eventually, the Ottomans enforced a tighter control on the region, effected under Phanariote hospodars (who were appointed directly by the Porte).
This suggests that these cells do not tolerate high levels of NFIX and thus its transcription is under a very tight control, even under heat shock conditions.
Our patient's blood pressure has remained under tight control with an angiotensin-converting enzyme inhibitor as well as a beta blocker.
The emotional woman said that her "friend" was only ever allowed out of the home to hang washing out and occasionally walk to a shop under the tight control of one of their alleged captors.
The federal government and the International Whaling Commission allow the whale hunt to continue, under tight control, as a subsistence tradition.
In vertebrates, autoreactive T cells are kept under tight control by a number of mechanisms, including the suppressive effect of regulatory T cells.
