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We discuss the issues raised and point to future research in Section 5. Imagine a three-stage trial initially involving K experimental treatments and a control group.
We refer to this approach as unconditional because, in a three-stage trial, for example, it produces an estimate of the treatment effect regardless of whether the trial stops at stage one, two, or three and it is therefore unbiased by definition when one averages across all possible realizations of the sequential trial.
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Before the F.D.A. approves a new medicine, the drug must survive testing for safety and efficacy in a three-stage sequence of trials, each of them involving a larger sample and more rigorous methods.
We followed a three-stage process of developing the network, prioritizing proposed trials, and implementing learning exercises that culminated in a 1-day network meeting at the end of the year.
A three-stage battle followed.
We envision a three-stage process.
The statistical plan called for a three-stage design.
Benjamin was referring to the second of Virginia's two-stage trial process.
Data are reviewed upon completion of patient accrual to the first stage of a two-stage phase II cancer clinical trial and prior to initiating accrual on the second stage.
A clinical trial using a two-stage phase II design to assess the response rate and safety profile of imatinib at a dose of 400 mg given twice daily in patients with advanced carcinoid tumors was completed.
Next consider a two-stage game.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com