The phrase "a three phase trial" is correct and usable in written English.
It can be used when referring to a trial or study that is conducted in three distinct phases or stages.
Example: "The researchers conducted a three phase trial to evaluate the effectiveness of the new medication."
Alternatives: "a tri-phase trial" or "a three-stage trial".
Here, we describe a series of three phase one trials in which abiraterone acetate was tested in humans for the first time.
A series of three phase I trials investigating the ability of AA to cause maximum suppression of testosterone synthesis when given to castrate and noncastrate males with prostate cancer has been conducted (O'Donnell et al, 2004).
The doxorubicin dose in the CAP regimen is lower than the dose used in the GOG-122 trial but a recent retrospective analysis of three phase III trials in 630 patients indicated that the risk of cardiotoxicity (ie irreversible cardiac heart failure) began to increase with cumulative doses of conventional doxorubicin as low as 300 mg m−2 (Swain et al, 2003).
Interestingly, a meta-analysis of three phase III trials in patients with metastatic colorectal cancer found an overall survival benefit to the chronomodulated schedule for men, but not for women [ 24].
10 In a pooled analysis of the three Phase III trials evaluating add-on saxagliptin 5 mg, the incidence of reported hypoglycemia was 8.3% in the saxagliptin arms compared with 6.8% in the placebo arms.
In a phase two trial, three different nab-paclitaxel regimens (300 mg/m q3w, 100 mg/m, or 150 mg/m given weekly for the first 3 of 4 weeks [qw 3/4]) were compared with docetaxel 100 mg/m q3w for the treatment of chemotherapy-naive patients with MBC [ 12, 13].
Concerns relating to the development or progression of diabetic retinopathy by insulin glargine were alleviated when in both a meta-analysis of four phase 3 trials (16) and a randomized control trial over a 5-year period revealed no difference between NPH and insulin glargine (17).
1 A total of five Phase III trials of ospemifene were conducted.
61 The multikinase inhibitor sorafenib has also been investigated in combination with bevacizumab in a series of two phase 1 trials.
The ECOG trial E1690 was a three arm phase III clinical trial, and had treatment arms of high dose interferon, low dose interferon, and observation.
Conversely, we chose to avoid strategies based on adding a consolidation or a maintenance therapy since two phase III trials had been terminated early on the evidence of futility of treatments and an increase of toxicities.
