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The phrase "a thoroughly different and" is correct and usable in written English.
It can be used to emphasize a significant difference between two or more things, often in a comparative context.
Example: "The new policy is a thoroughly different and more effective approach to addressing the issue."
Alternatives: "a completely different and" or "an entirely different and".
Exact(1)
We investigate a thoroughly different and highly extensible solution based on semantic matching where labels are parsed by multilingual natural language processing and then matched using language-independent and domain aware background knowledge acting as an interlingua.
Similar(59)
To presume that life began with an asexual, random mutation evolutionary process, and at some point switched to a thoroughly different process based on sex and nonrandom mutation introduces an arbitrary line into history and into theory of the kind that we should be happy to remove and that shows a disagreement between this hypothetical origin scenario and the theory presented here.
"Latin music" is an enormous category, and Tito Puente was a thoroughly different entertainer from Mr. Caymmi.
It's a thoroughly different experience getting into a Betsey Johnson show.
Wambach is a thoroughly different player in a different era — partially her era, to be precise.
By the time of the C minor Sonata, composed in 1822, Beethoven was on a thoroughly different creative plane.
This underlines the fact that mourning can take place in a radically different way, based on a thoroughly different understanding of death, highlighting how any claims to a universal "psychology of grief" pale in the face of human diversity.
Sliced conch with wild pepper sauce ($6.95), made with Sichuan peppercorns, offers a thoroughly different sensation in which the pepper sets the mouth atingle, as if the food were dancing across the tongue.
Students can be asked to look at just skeletons of birds and fishes and discuss how we might use a similar body plan in both, but through evolutionary (non-magic) change, adapt a body plan – a "morphology" – to a thoroughly different environment.
Was it due to differences in how thoroughly different ICUs implemented the changes?
If you go on four, scintillating, thoroughly different holidays through a calendar year, each return to the treadmill will (I promise) be painless.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com