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The phrase "a thoroughgoing knowledge" is correct and usable in written English
It can be used to describe a deep and comprehensive understanding of a subject or topic. Example: "To excel in this field, one must possess a thoroughgoing knowledge of the principles and practices involved."
Exact(3)
Though Mr. Conrad -- the author of earlier books like "Imagining America" and "Modern Times, Modern Places" -- often undermines the points he wants to make with pretentious academic posturing, he demonstrates a thoroughgoing knowledge of Hitchcock's films and manages in these pages to do a first-rate job of situating the director's work in the context of modernist, post-World War I art.
He lists their "deeply shared and permeating artistic beliefs": "a mutually embraced ethnicity and a binding aesthetic; a methodical approach to creativity; a blending of pragmatism and idealism; a veneration of classical order and structure; a thoroughgoing knowledge of and affinity for the other's art".
We've established before that this is not a crowd that embraces a thoroughgoing knowledge of history in general, and it's probably fair to assume a knowledge of theatrical history not at all.
Similar(57)
Dimitri was a thoroughgoing modernist.
"He's technically a thoroughgoing expert.
If you are after a thoroughgoing scholarly treatment, look elsewhere.
Needless to say, Mellon was a thoroughgoing horse lover.
A thoroughgoing merger wave, however, may have to wait until 2005.
Why would a smart, comically capable young man be such a thoroughgoing mess?
He was a thoroughgoing republican with a deep dislike of the kaiser and all hereditary power.
He was, by his own lights and that of his admirers, a thoroughgoing contrarian.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com