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The phrase "a thorough familiarity" is correct and usable in written English.
It can be used when discussing someone's deep understanding or knowledge of a subject or topic.
Example: "To excel in this role, you must have a thorough familiarity with the company's policies and procedures."
Alternatives: "a deep understanding" or "a comprehensive knowledge".
Exact(8)
There is diligence in this book, and a thorough familiarity with the paper trail of bin Laden.
After all, many of us have a general sense of, if not a thorough familiarity with, the contents within.
Communicating a Broadway show to the deaf demands not just a knowledge of sign language, Ms. Penn and Mr. Champion say, but a thorough familiarity with the production.
Petrological research requires a strong understanding of the principles of mineralogy and mineral identification and a thorough familiarity with the theoretical and experimental studies of rock origins.
Indeed, his writings testify to a thorough familiarity with Greek philosophy and science as read by the Muslim philosophers al-Farabi and Ibn Sina, as well as with rabbinic literature, Hebrew poetry, and Jewish philosophy.
The first step was to read the data carefully to gain a thorough familiarity with them.
Similar(52)
Difficulties should be anticipated based on thorough familiarity with the implant design and on evaluations of implant fixation and bone stock.
Alexander's discussions confirm not only his thorough familiarity with Aristotle's ethics, but also reflect the debates of the Peripatetics with the Epicureans and Stoics in Hellenistic times, as shown especially by Alexander's terminology.
Statistician Anthony Edwards praised not only the book's groundbreaking content, writing that it demonstrated Bernoulli's "thorough familiarity with the many facets [of combinatorics]," but its form: "[Ars Conjectandi] is a very well-written book, excellently constructed".
All the transcripts were read and re-read several times to gain thorough familiarity with the responses.
Thorough familiarity with the responses was gained by reading and re-reading all of the transcripts several times.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com