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At a third occurrence of >grade 1 toxicity, sunitinib was discontinued.
Afatinib was discontinued after a third occurrence of AEs as specified above.
Capecitabine doses were reduced by 50% for patients who experienced a third occurrence of a given grade 2 event, a second occurrence of a given grade 3 event, or any grade 4 event.
Capecitabine doses were reduced by 50% to 500 mg m−2 twice daily for patients who experienced a third occurrence of a given grade 2 event, a second occurrence of a given grade 3 event, or any grade 4 event.
If patients experienced a third occurrence of a given grade 2 toxicity, a second occurrence of a given grade 3 toxicity, or any grade 4 toxicity, both doses were reduced by 40%.
Capecitabine doses were reduced by 40% for a first occurrence of grade 4 haematological toxicity, a second occurrence of grade 3 haematological toxicity, any grade 4 non-haematological toxicity, a second occurrence of grade 3 non-haematological toxicity or a third occurrence of grade 2 non-haematological toxicity.
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The drug was discontinued in case of a second occurrence of severe toxicity.
If a second occurrence of >grade 1 toxicity occurred, sunitinib was further reduced to 12.5 mg.
The patient discontinued volasertib after a second occurrence of DLT (grade 4 thrombocytopenia) at 300 mg.
Capecitabine doses were reduced by 20% for patients who experienced a first occurrence of a grade 3 haematological toxicity, a second occurrence of grade 2 non-haematological toxicity or any grade 3 non-haematological toxicity.
A Cox model was used to identify the correlates of a first occurrence of a major CADE.
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