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A second necessity is to give interest rate relief on sovereign debt, to lessen the ramifications of the excessive debt in the financial system.
Despite unclear upstream mechanisms, NLRP3 is expressed at limiting levels in macrophages or dendritic cells, possibly to avoid unintended inflammation, and requires a PRR-dependent priming signal via TLRs as a first necessity for its subsequent activation (Bauernfeind et al, 2009; Juliana et al, 2012).
The third necessity is the ability to attract good people to work in government.
The first necessity is a development of a guideline for economic evaluations.
The first necessity for a blank slate is an omnipotent eraser, and the guillotine was the one at hand.
Whether the structure is a single-family house or a thirty-story building, the first necessity is that every room have light and air.
The first necessity is a reform of the Greek economic structure.
A visit to the camp barber was the first necessity for the recruits, where a close "number one" cut was the only style on offer.
The first necessity was to establish a legitimate basis of action.
The first necessity for organizational health is building a cohesive leadership team.
The first necessity for Mrs. Clinton — high turnout — is a virtual certainty.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com