Sentence examples for a template structure from inspiring English sources
The most successful type of structure prediction, known as homology modeling, relies on the existence of a "template" structure with sequence similarity to the protein being modeled; structural genomics' goal is to provide sufficient representation in solved structures to model most of those that remain.
Pharmacological investigations progressed to rational design using the 1st generation compounds as a template structure.
Homology modeling of CCR1 was performed based on a template structure (4EA3) which has a high sequence identity and resolution.
For both connection methods, and for all of the other primitives described in this section, the combination of the initial structure and a template structure can require some additional cleanup, since atoms and bonds can overlap.
Finally, the architecture aims to be modular in the front- and back-end of the client server architecture, meaning that there is a template structure for the basic features of a processing module.
As no crystal structure of the enzyme has yet been published, we built a homology model of aromatase using the first crystallized mammalian cytochrome enzyme, rabbit 21-progesterone hydroxylase 2C5, as a template structure.
A variety of alternative profile generation mechanisms have been explored, embedded within an template structure based on the model in [2]; see Figure 7.
FFAS03 returns standardized variable ("Z") scores for comparisons between a query and a solved template structure sequence, with a score of 9.5 cited by the authors as being statistically significant.
A target has a similar length to an available template structure but it is missing a structural feature e.g. the TMH6-ECL3 disulphide bridge in hAA2AR.
In almost every test case, both MEDELLER and Modeller could create a better core model when given only a single template structure (e.g. the one with the highest sequence identity to the target).
In the proposed model, this concept is recognized by a new template structure including the appearance filters, constraints, and a set of parameters trained by latent SVM.
