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Strain engineering for industrial production requires a targeted improvement of multiple complex traits, which range from pathway flux to tolerance to mixed sugar utilization.
However, it must be noted that the sample size calculation operates within the context of a targeted improvement that is a relative one.
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This new understanding provides a foundation for targeted improvement activities, such that return on investment in the production of evidence will be optimised and its relevance enhanced.
Specifically, 40% of aggressively treated subjects are dead at one year after the index visit, suggesting a potential opportunity for targeted improvement, particularly for investigators designing trials that target longer term outcomes.
A risk-index score as a function of time may represent a useful tool for the assessment of targeted improvement interventions, given its use of a non-rate-based measure.
Therefore, in-depth characterization of the cellular response upon long-term production is of high interest for the targeted improvement of a desired strain.
1 Conventionally, the overall sample size for a clinical trial with a time-to-event endpoint depends on: the targeted improvement in the hazard ratio (relative improvement in the median OS, PFS, or TTP); and the type I and type II error (equivalently significance level and power) Together, these 2 factors determine the number of events required (deaths/disease progressions).
City authorities should approach and plan greening 'for' (not 'in') informal settlements as a targeted environmental improvement endeavour – referred to here as 'creative urban planning'.
As a result, satellite manufacturers may wish to pursue targeted improvement to this subsystem, either through better testing or burn-in procedures, better design or parts selection, or additional redundancy.
This targeted improvement was then applied as a global goal to achieve similar progress worldwide from 1990 2015.
We targeted improvement of ANC services because ANC is a vital point of entry for most high-impact interventions targeting the pregnant mother.
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