TOC Summary: A targeted, hypothesis-based approach and local surveys over broad geographic areas are needed.
This was a targeted hypothesis-driven study of a single gene, focusing on specific markers that have been strongly implicated in multiple prior reports of language-related disorder, rather than a genome-wide search for new variants.
This ignored multiple-hypothesis testing issues and represented the situation where there existed a targeted replication hypothesis.
Together, these analyses provide one of the first interdisciplinary descriptions of sites within this massive seep system, setting the stage for more targeted, hypothesis-driven investigations.
6, 7 Having identified this unexpected association, we posed two targeted hypotheses.
The major advantage of high-throughput approaches over more targeted hypothesis-driven strategies is their capacity to collect large amounts of information about a specific phenotype or disease condition in an unbiased manner.
As above mentioned, each study (which is represented by a row of the database) can be envisaged as a working hypothesis about a targeted therapy against melanoma.
To reduce the multiplicity of hypothesis testing, a targeted approach was adopted.
We built on these findings to test the hypothesis that a targeted educational intervention can maximize the benefits of other mitigation efforts on the exposure of children.
A randomised controlled trial with focus on the effects of an ADL intervention among disabled cancer patients was designed to test the hypothesis that a targeted ADL intervention could enhance participation in everyday activities and improve quality of life of patients with cancer.
The chapter also presents the functional assessment and analysis methods to identify the factors that maintain a targeted behavior, and to develop hypotheses regarding how those factors interplay with the behavior.
