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The fact that the TMS stimulation used in the study had such a targeted effect on memory networks makes Voss optimistic that the technology could counteract memory loss.
However, the Context participants had longer fixation durations, and there was a targeted effect of looks at the car with the bomb the first time it is on the screen for No-context participants.
The proposed framework stipulates the use of a state-space representation to define when, where, for whom, and in what state for that person, an intervention will produce a targeted effect.
Our results suggest Rag2 may have a targeted effect on aphids, potentially associated with the production of specific allelochemicals.
Thus we hypothesized that the DNMT inhibitors AZA and DAC could have a targeted effect on AML1/ETO-positive leukemic cells, and be active at lower doses.
Taken together, with the lack of modulation of CYP2J26, these results suggest that the reduction in gene expression is a targeted effect of methanol treatment.
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What makes them different, he said, is that the whole point of a drug is to have a very targeted effect from the lowest dose possible.
Given the complexity of AD, a clear distinction is lacking as to whether the expression of DNA-PK subunits may have been transcriptionally impaired in AD brains because of a hitherto unknown upstream event that is too generic to have a specifically targeted effect on DNA-PK.
Several mechanisms have been proposed to explain immunotoxin-mediated thrombotic microangiopathy, including toxin-mediated endothelial damage (off-target and targeted effect) and a general proinflammatory response.
Similar to those of A-729611, the targeted effects of FLB-12 are PXR-specific, with no effects on other orphan nuclear receptors [ 77].
Additionally, the conjugation of target molecules to these nanocarriers would allow the selective delivery of chemotherapeutic agents to tumor sites with reduced peripheral exposure through a tumor cell surface receptor-mediated targeted effect [17 19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com