Sentence examples for a target of activated from inspiring English sources

The RBD domain is a target of activated Rho proteins, small GTPases cycling between an active GTP-bound and an inactive GDP-bound conformation [19].

The evidences that overexpression of SAF-1/MAZ occurs in many human cancers and SAF-1/MAZ transcription factor is a target of activated Ras proteins, raised the questions, what downstream pathways are affected during aberrant activation of SAF-1 in cancer.

Abundance of phosphorylated protein kinase B/Akt, a target of activated MR, was not altered by CsA.

Further confirmation of apoptosis was obtained by Western blotting for PARP protein, a target of activated caspases during apoptosis.

Thus, various lines of evidence suggest that PIAS1 is a target of activated JNK, although additional experiments are required to identify specific modified residues.

InS3-54 trealsont also induced cleavage of PARP in breast cancer cell line MDA-MB-468 (data not shown), a target of activated caspases during execution of apoptosis, confirming that 72-h treatments with inS3-54 induce apoptosis.

The latter is a target of kinases activated by different stimuli.

p21 is a target gene of activated p53 that is transcriptionally induced following DNA damage.

Cyp4a8 is also a target of PPARα (peroxisome proliferator activated receptor alpha) signaling [ 55] and its expression has been suggested to explain sex and strain differences in the susceptibility to hypertension and target organ damage [ 56].

Recent reports have suggested that AKT, a target of PI3K, is phosphorylated and thus activated under basal conditions in a variety of pancreatic cancer cell lines (Xue et al, 2000; Bondar et al, 2002; Samatar et al, 2002).

The PG gene has been previously shown to be a target of two pro-oncogenic pathways frequently activated in colorectal cancer: APC/β-catenin and K-ras [ 35- 37].