Sentence examples for a target for lowering from inspiring English sources
The pharmacological and genetic evidence cited above validate gamma-secretase as a target for lowering Aβ production as well as non-target organ side effects due to inhibition of Notch signaling.
Further research is needed to verify this and some of the other suggestive conclusions, but, despite the preliminary nature of some of our results, the most poignant implication of this study is that prevention and management of bacterial infections in the biliary tract may be a target for lowering the risks of cholesterol gallstones.
Phosphorylated PDGFR- β, a stromal tyrosine kinase receptor, is recognised as a strategic target for lowering IFP in tumours overexpressing PDGFR- β.
Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as a therapy for Alzheimer's disease (AD).
This enzyme is considered to be a useful target for lowering serum cholesterol levels [41] and is active as a homodimer [41].
Thus, NPC1L1 is a proven target for lowering cholesterol from both dietary absorption and hepatic reabsorption.
Using this strategy, we have found that KIAA1363 is a novel target for lowering key pro-inflammatory cytokines through affecting key ether lipid metabolism pathways.
Promoting HDL-C is now emerging as an important target for lowering the risk of CVD in the population.
The suggestion that SEC24A may be a target for LDL lowering is premature, especially given the fact that there are phenotypic effects of inactivating Sec24A that are not due to a deficiency of PCSK9, including mild increases in RBC MCV and MCHC, and a >50% reduction in SCD1 mRNA.
This study also suggests myosin II as a potential therapeutic target for lowering intraocular pressure in patients with glaucoma.
Taken together, BACE1 characterization and validation studies have unequivocally demonstrated that BACE1 is the authentic β-secretase in the brain and that it is a promising therapeutic target for lowering cerebral Aβ levels.
